Hemodialysis Re-envisioned: The Contributions of New Biomaterials

01/29/2018 - 3:00pm
LEADERSHIP SEMINAR SERIES: Buddy D. Ratner, Ph.D., Professor of Bioengineering and Chemical Engineering, Michael L. & Myrna Darland Endowed Chair in Technology Commercialization, University of Washington
Communicore, C1-15

Chronic hemodialysis on humans was first used successfully to address end stage kidney disease (ESKD) in 1962. Since that time, we now have 2 million people worldwide receiving dialysis treatments three times a week – the therapy sustains their lives. However, the complications of kidney dialysis are tragic for ESKD patients and the costs to society are huge (>$100B/yr). The Center For Dialysis Innovation (CDI) at the University of Washington is focused on rethinking how we do dialysis. We aim to develop a 24/7 ambulatory dialysis system, the AKTIV (Ambulatory Kidney to Improve Vitality). To retool dialysis, we will need improved blood waste cleansing (next-generation membranes), novel biosensors, excellent blood compatibility, durable blood access, resistance to biofilms and solid device engineering. Many technologies associated with biomaterials will be integrated into the AKTIV including non-fouling surfaces, new blood compatible materials, skin healing and vascular prostheses. A number of these enhancements that may revolutionize how dialysis is performed today will be discussed in this talk.

Dr. Buddy D. Ratner is the Director of University of Washington Engineered Biomaterials (UWEB21) Engineering Research Center, co-director of the Center for Dialysis Innovation (CDI) and the Darland Endowed Chair in Technology Commercialization. He is a professor of bioengineering and chemical engineering at the University of Washington. Ratner received his Ph.D. (1972) in polymer chemistry from the Polytechnic Institute of Brooklyn. Ratner is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), AVS, AAAS, ACS, POLY and the International College of Fellows Biomaterials Science and Engineering. In 2002 Ratner was elected a member of the National Academy of Engineering, USA. He has been involved in the launch of seven companies and won numerous awards including the AVS Welch Award (2002), Society for Biomaterials Founders Award (2004), the BMES Pritzker Distinguished Lecturer Award (2008), the Acta Biomaterialia Gold Medal (2009), the Galletti Award (2011) the George Winter Award of the European Society for Biomaterials (2012) and the University of Washington School of Medicine Lifetime Innovator and Inventor Award (2014). His research interests include biomaterials, tissue engineering, regenerative medicine, polymers, biocompatibility, surface analysis and plasma thin film deposition.

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