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Brandi K. Ormerod, Ph.D.
Brandi K. Ormerod, Ph.D.
Associate Professor & Director, BME Graduate Student Diversity & Professional Development
Engineered stem cell and immunomodulatory strategies
1275 Center Drive, Biomedical Sciences Building J296, Gainesville, FL 32611
B.Sc. (Honors), Biopsychology, Queen's University, 1998
NSERC and Killam Ph.D., Neuroscience, University of British Columbia, 2003
NSERC and MJFF Postdoctoral Fellow, Stanford University
Dr. Ormerod’s research focuses on understanding how to use transplantable or endogenous neural stem cells to repair neural circuits in the diseased or injured brain and how changes in levels of hippocampal neurogenesis across lifespan impact cognition. Projects seek to 1) identify pro-geronic factors that impact hippocampal neurogenesis and memory and develop detection assays and strategies to modulate them, 2) identify inflammatory and neuroinflammatory factors that regulate neural stem cell behavior and cognition and develop strategies to modulate them, and 3) identify the functional impact of neuronal addition to diseased or damaged neural circuits. Multidisciplinary projects employ rodents or culture systems that integrate numerous techniques that include behavioral testing, protein quantification using multiplex technology, MEA-monitoring of neuronal activity, and the quantification of cultured and endogenous cell behavior with advanced immunohistochemical and histological techniques, among others.
Honors and Awards:
- Ruth K. Broad Biomedical Research Foundation Extramural Investigator, 2008-2010
- Fellow, Michael J. Fox Foundation Postdoctoral, 2003-2006
- Fellow, Natural Sciences and Engineering Research Council of Canada Predoctoral, 2004-2006
Speisman, RB, Kumar A, Rani A, Pastoriza JM, Severance JE, Foster TC and Ormerod BK (2013). Environmental enrichment restores neurogenesis and rapid acquisition in aged rats. Neurobiol Aging. 34:263-274. PMID: 22795793.
Speisman RB, Kumar A, Rani A, Foster TC and Ormerod BK (2013). Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats. Brain, Behavior and Immunity, 28:25-43. PMID: 23078985.
Ormerod BK, Hanft SJ, Asokan A, Haditsch U, Lee SW and Palmer TD (2013). PPARg activation prevents impairments in spatial memory and neurogenesis following transient illness. Brain, Behav Immun, 29:28-38. PMID: 23108061.
Stephens CL, Toda H., Palmer TD, DeMarse TB and Ormerod BK (2012). Adult neural progenitor cells reactivate superbursting in mature neural networks. Experimental Neurology, 234:20-30. PMID: 22198136.
Ormerod BK., Palmer TD and Caldwell MA (2008). Neurodegeneration and Cell Replacement. Philosophical Transactions of the Royal Society: Biological Sciences, 363; 153-170. PMID: 17331894.