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Elena Yarmola, Ph.D.
Elena Yarmola, Ph.D.
Research Associate Scientist
1275 Center Drive, Biomedical Sciences Building J327, Gainesville, FL 32611
M.S., Physics and Engineering. Moscow Institute of Physics and Technology, Moscow, Russia, 1980
Ph.D., Molecular Biophysics. Moscow State University, 1986
Molecular biophysics and spectroscopy: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 1986-1998
Biochemistry: University of Florida Department of Medicine (NIH National Research Service award), 2000-2001
Cell biology and immunology: University of Florida Department of Medicine (NIH National Research Service award), 2003-2010
Dr. Yarmola’s recent work is focused on the development and advancement of a new magnetic nanoparticle technology for the collection of joint-level molecular biomarkers, termed magnetic capture. Biomarker development for osteoarthritis (OA) often begins in rodent models, but can be limited by the inability to aspirate synovial fluid from the joint. Magnetic capture is able to indirectly assess biomarkers in synovial fluid without the need for aspiration. Further development of this technology will lead to better understanding of the links between OA-related pathogenesis and OA-related pain and disability. This technology provides the ability to develop diagnostic and prognostic OA biomarkers that will improve patient outcomes for OA.
Dr. Yarmola’s long-term research interests encompass biophysics, biochemistry, structural biology, immunology, biomedical engineering, and nanotechnology. Her prior work accomplishments include: a) a new paradigm for regulated actin polymerization in cell motility; b) novel experimental techniques based on fluorescence anisotropy; c) precise models for DNA and protein movement through gels; d) innovative approaches in the low-temperature magnetic circular dichroism spectroscopy; d) determination of the effective electrostatic diameter of the DNA double helix—a general characteristic of the electrostatic interactions between DNA segments.
During her career, Dr. Yarmola has combined mathematical, computational, and experimental approaches in her research. With the goal to stay on the cutting edge of science and technology, she is eager to learn about new scientific discoveries, techniques, and technologies and to incorporate these new ideas into her research.
Honors and Awards:
· Department of Veterans Affairs BLR&D Intramural Program, 2010
· ICI/FOCIS Travel award, 2005
· Career Development Award (K25) from the National Institutes of Health (NIH), 2003
· National Research Service Award (T32, NIH), 2000
· Award from Biophysical Society and International Science Foundation, 1995
· International Science Foundation Award, 1992
· Outstanding Young Scientist award, Institute of Molecular Biology, Moscow, 1998
Selected Publications (out of 38 peer-reviewed publications)
Yarmola EG, Shah YY, Kloefkorn HE, Dobson J, Allen KD. Comparing Intra-articular Levels Assessed via Magnetic Capture or Lavage in a Rat Knee Osteoarthritis Model. Osteoarthritis and Cartilage 2017 Jan 27. [Epub ahead of print].
Yarmola EG, Shah Y, Arnold DP, Dobson J, Allen KD. Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee Osteoarthritis. Ann Biomed Eng. 2016, 44:1159.
Yarmola EG, Bubb MR. How depolymerization can promote polymerization: the case of actin and profilin. BioEssays. 2009; 31:1150 (Cover highlight).
Yarmola EG, Dranishnikov DA, Bubb MR. Effect of profilin on actin critical concentration: a theoretical analysis. Biophys J. 2008; 95:5544.
Yarmola EG, Bubb MR. Profilin: emerging concepts and lingering misconceptions. Trends Biochem Sci. 2006; 31:197.
Yarmola EG, Bubb MR. Effects of profilin and thymosin beta 4 on the critical concentration of actin demonstrated in vitro and in cell extracts with a novel direct assay. J Biol Chem. 2004; 279:33519.
Yarmola E, Calabrese, P.P. Chrambach A, Weiss, G.H. Interaction with the matrix: the dominant factor in macromolecular band spreading in gel. J. Phys. Chem. 1997; 101:2381.
Yarmola EG, Sharonov YA. Low-temperature magnetic circular dichroism investigation of the active site of chloroperoxidase. FEBS Lett. 1994; 355:279.
Yarmola EG, Zarudnaya MI, Lazurkin YuS. Osmotic pressure of DNA solutions and effective diameter of the double helix. J Biomol Struct Dyn. 1985; 2:981.