Congrats to Drs Buchwald, as well Dr. Tomei and her lab, for the recent publication of our collaborative work on examining the impact of alginate encapsulation of human islets on their dynamic responses to glucose stimulation. This study developed a robust computational model to predict the impact of alginate encapsulation, as well as the size of this barrier, on the ability of the islet to respond to a glucose challenge. These results will help lead the discussion on the impact of this barrier on the ability of these transplanted islets to physiologically regulate blood glucose in vivo. Congrats to a wonderful collaborative effort!
