Jaime Giraldo lead our recently published study, a collaborative effort between our lab and Dr. Antonello Pileggi’s team, examining the impact of polymeric surface engineering on masking immune recognition and the complementary effects of short-course immunotherapy. Jaime found a strong immunoprotective benefit using this simple PEGylation coating, as well as a synergistic impact when paired with the delivery of an Lymphocyte Function-associated Antigen-1 blocking antibody. This optimized PEG coating is now being transitioned to stronger preclinical models in an effort to bring this approach to the clinic!
Congrats to Jaime and team!!