Category: Stabler Laboratory – Diabetes Tissue Engineering

Congratulations to Dr Ying Li on the successful defense of her PhD dissertation entitled “The Mechanistic Study of Host Adaptive Immune Responses to Microencapsulated Cellular Grafts using an Antigen-Specific In Vitro Model”! Her work provides a platform to investigate and manipulate immune responses to encapsulated cells, which can provide insight into ways to elevate the […]

Ying Li, along with fellow doctoral students Anthony Frei, Ethan Y Yang, and Magdalena Samojlik, MS researchers Chuqiao Sun and Yanan Rong, lab manager Irayme Labrada-Miravet, and in collaboration with Dr Bayer, recently published our findings on investigating the role of the adaptive arm of the immune system in the recognition and attack of encapsulated […]

A BIG congratulations to, Jiapu Liang, who will be awarded the Mary Ann Liebert, Inc. Outstanding Student Award during the upcoming 2020 TERMIS-AM Conference. The TERMIS-AM Outstanding Student Award recognizes a student “who has shown outstanding research accomplishments within the tissue engineering and regenerative medicine field.”. The nomination is based on student contributions and a […]

We have recently published our highly collaborative work on the use of PEG grafting of islets to improve transplant outcomes. This work establishes the significant benefits of linking single chain polymers to the islet surface, with significantly improved islet survival and function long term. This manuscript, lead by Dr Stabler and Dr Norma Kenyon at […]

Sydney Wiggins, along with fellow doctoral student Nicolas Abuid, research assistant scientist Kerim Gattás-Asfura, and masters student Saumadritaa Kar recently published their review article on nanotechnology approaches in Type 1 diabetes technologies. This review highlights use of nanotechnologies, from nano-scale coatings to nanoparticles for improving beta cell replacement. Congrats to Syd, Nic, Kerim, and Saumadritaa! […]

We are pleased to share our recent review, a collaborative effort with Dr Keselowsky and our doctoral students Ying Li and Joshua Stewart, on the use of immunomodulatory materials in type 1 diabetes, This review highlights use of materials for both prevention and treatment of diabetes, from engineering vaccines to improving beta cell replacement. Check […]

Maria Coronel, along with fellow doctoral students Jiapu Liang and Ying Li, recently published our findings on the translation of our oxygen generating material, OxySite, into macroencapsulation devices. This manuscript, published in the journal Biomaterials, evaluates the capacity of OxySite to supplement beta cells within macroencapsulation devices, which are notoriously hypoxic. These findings outline the […]

Nicholas Abuid, along with research assistant scientist Kerim Gattás Asfura, and undergraduate student Emily Schofield recently published our findings on the fabrication of antioxidant layer-by-layer coating for protecting encapsulated cells from free radical damage. This manuscript, published in the journal Advanced Healthcare Materials, evaluates the capacity of cerium oxide nanoparticle layers to protect encapsulated beta […]

Kaiyuan Jiang, along with postdoctoral fellow Deborah Chaimov and graduate students Smit Patel, Jiapu Liang, Sydney Wiggins, and Magda Samojlik,and in collaboration with Dr. Cheslea Simmons’ lab at UF, recently published our findings on the fabrication of decellularized extracellular matrix (ECM) hydrogels for islet culture. This manuscript, published in the journal Biomaterials, evaluates the capacity of […]

Congrats to Drs Weaver, a Stabler lab PhD alumni, as well Dr. Garcia, her current postdoctoral advisor and corresponding author, and the rest of his team, on their recent publication of our collaborative work on examining the impact of vascularization of macroencapsulation platforms. These results will help improve the engraftment of islet transplants that are immunoisolated […]

Dr. Stabler was recently elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows! The College of Fellows is comprised of outstanding bioengineers in academia, industry and government, representing the top 2 % of medical and biological engineering professionals. Stabler was elected for her outstanding contributions in the design of translational bioactive materials for cellular transplantation, […]

Congrats to Drs Buchwald, as well Dr. Tomei and her lab, for the recent publication of our collaborative work on examining the impact of alginate encapsulation of human islets on their dynamic responses to glucose stimulation. This study developed a robust computational model to predict the impact of alginate encapsulation, as well as the size of […]

The Stabler lab will be coming to BMES 2017 in Phoenix Az from Oct 11-14. We are excited to have the opportunity to present our work in many forms. Please attend our talks or swing by our posters to learn about some of our current research!  Ying Li will be presenting her work, supported by Anthony […]

Anthony Frei, along with graduate students Ying Li, Kaiyuan Jiang, and in collaboration with Dr. Buchwald at UMiami, recently published our findings on the impact of the local release of figolimod, a promising immunomodulatory and pro-angiogenic agent, from macroporous scaffolds on islet survival and function. This manuscript, published in the Journal of Tissue Engineering and […]

It has been a busy month in the Stabler lab, with both Kaiyuan Jiang and Anthony Frei successfully defending their PhD theses! Dr. Jiang defended his dissertation entitled “LOCAL MODIFICATION OF POLYDIMETHYLSILOXANE-BASED SCAFFOLD IMPLANTS TO IMPROVE ISLET GRAFT EFFICACY AND MODULATE HOST RESPONSE”, where he highlighted the important of modulating inflammation within the islet microenvironment. Dr. Frei defended […]

Congrats to Drs Buchwald and Ricordi, as well as lead authors Marta and Alejandro, for the recent publication of our collaborative work on examining the impact of low oxygen and inflammatory signals on the metabolomic profile of human pancreatic islets. This study may help lead to the identification of potential biomarkers and provide another means to track […]

Maria Coronel, along with Ryan Geusz (undergraduate student), recently published their findings on the impact of our patented oxygen generating biomaterial, OxySite, on mitigating stress and damage in pancreatic islets under low oxygen tension (hypoxia). This manuscript, published in the journal Biomaterials, provides guidance as to the detrimental impact of low oxygenation, a common problem […]

Our collaborative work with Dr. Ashu Agarwal’s and Dr. Buchwald’s team at the University of Miami was recently published in the journal Lab on a Chip. This work, led by Dr. Agarwal’s postdoctoral fellow Dr. Lenguito, highlights the engineering of fluidic platforms for islet interrogation and is the first step in our research in engineering optimal culture devices for islets and beta […]

Even our islets are sharing in the love today. Kerim Gattas-Asfura (Research Assistant Scientist) and Nicholas Abuid (graduate student) took this photo of an islet encapsulated in a nanothin polymer (the red color comes from the labeled polymer) that serves to protect it from immune recognition and attack

Jaime Giraldo lead our recently published study, a collaborative effort between our lab and Dr. Antonello Pileggi’s team, examining the impact of polymeric surface engineering on masking immune recognition and the complementary effects of short-course immunotherapy. Jaime found a strong immunoprotective benefit using this simple PEGylation coating, as well as a synergistic impact when paired […]

Kaiyuan Jiang, along with Jessica Weaver (alumni of lab), Yangjunyi Li and Xiogjian Chen (MS students in lab), and Jiapu Liang (PhD student in lab), recently published their findings on the impact of local delivery of dexamethasone, a potent anti-inflammatory agent, on improving islet engraftment in the journal Biomaterials. Kaiyuan found that the local release of […]

Congratulations to Maria Coronel for the successful defense of her Doctoral dissertation “Engineering an In Situ Oxygen Generating Biomaterial for Extrahepatic Islet Transplantation”! We look forward to great things from Dr. Coronel!    

The Stabler Lab had a great meeting with their collaborative team on the NIH CHIB grant (Drs Agarwal and Stabler), as well as the other teams on the consortium, in Philadelphia on Oct 27th. The team presented their findings and demonstrated their devices to the rest of the NIH CHIB consortium members.  

We are happy to welcome two new PhD students to the Stabler lab team! Sydney Wiggins and Smit Patel have joined this lab this month after joining the UF BME PhD department in the Fall of 2016. Look for amazing work coming from these fantastic new additions!