Dr. Parisa Rashidi (Contact PI), Dr. Azra Bihorac (Co-PI), and several other UF researchers were awarded an NIH National Institute of Neurological Disorders and Stroke (NINDS) grant for their project titled ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention.

Delirium is a common acute brain dysfunction syndrome affecting up to 50% of patients in the Intensive Care Unit (ICU). It is associated with prolonged ICU stay, increased mortality, long-term cognitive impairment, and an annual cost of $164 billion in the United States. Recent large-scale trials have shown no significant benefit of pharmacological interventions, and non-pharmacological approaches remain the cornerstone of delirium prevention. Among those strategies, minimizing patient immobility and circadian desynchrony due to sleep disruption and light and noise exposure are particularly difficult to implement, as their assessment is dependent on sporadic human observations.

Recent large-scale trials have shown no significant benefit of pharmacological interventions in delirium patients, and non-pharmacological approaches remain the cornerstone of delirium prevention.

The overall objective of this application is to develop ADAPT, the Autonomous Delirium Monitoring and Adaptive Prevention system, using novel pervasive sensing and Deep Learning (DL) techniques. It will autonomously quantify patients’ mobility and circadian desynchrony regarding nightly disruptions, light intensity, and sound pressure level. This will allow us to integrate these risk factors into a dynamic model for predicting delirium trajectories.

The proposed research is relevant to public health because it can enhance critical care workflow and early critical care intervention, ultimately improving patient outcomes and decreasing hospitalization costs.

The successful application of the proposed technology would augment clinical decision-making in the fast-paced ICU environment and promote more targeted interventions.

Researchers:

• Dr. Parisa Rashidi (Contact PI), Associate Professor and J. Crayton Pruitt Family Term Fellow, Department of Biomedical Engineering, University of Florida
• Dr. Azra Bihorac (Co-PI), Professor of Anesthesiology, Medicine, and Surgery, Department of Medicine, University of Florida
• Dr. Katharina Busl (Co-I), Associate Professor of Neurology and Neurosurgery; Chief, Division Of Neurocritical Care; Director, UF Health Shands Neurointensive Care Unit
• Dr. Michelle Gumz (Co-I), Associate Professor of Medicine in the Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida
• Dr. Tezcan Ozrazgat Baslanti (Co-I), Research Assistant Professor, Department of Medicine, University of Florida
• Marko Suvajdzic (Co-I), Associate Director and Associate Professor, College of the Arts, University of Florida