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Gregory Hudalla, Ph.D.
Gregory Hudalla, Ph.D.
Nanomaterials, implants, and immunotherapies
1275 Center Drive, Biomedical Sciences Building J293, Gainesville, FL 32611
B.S., Chemical Engineering, Illinois Institute of Technology, 2004
M.S., Biomedical Engineering, University of Wisconsin, 2006
Ph.D. Biomedical Engineering, University of Wisconsin, 2010
NIH NRSA Post-doctoral Fellow, Surgery, University of Chicago, 2013
Dr. Hudalla’s research creates functional materials for therapeutic or diagnostic applications via molecular self-assembly. Dr. Hudalla develops synthetic peptides that can assemble into a desired nano-scale architecture, and then use these peptides as “tags” to organize biologically active molecules into functional materials. This creates glycosylated materials to modulate the activity of carbohydrate-binding proteins by attaching carbohydrates to peptides that self-assemble into elongated nanofibers. In another project, we create peptides that co-assemble into prescribed nanofibers or globular coiled-coils only upon mixing, which when expressed as recombinant fusions with functional proteins of interest, direct the self-assembly of different proteins into multi-functional nanomaterials. Dr. Hudalla's long-term goals are to create biomaterials that can modulate immune responses for treatment of autoimmune diseases, or create biomaterials that interfere with molecular-level events central to metastasis and viral infection.
Honors and Awards:
- UF Pruitt Family Endowed Faculty Fellowship, 2017-2020
- Young Innovator by Cellular and Molecular Bioengineering, 2016
- NSF CAREER Award, 2015
- Faculty Teaching Excellence Award, University of Florida Department of Biomedical Engineering, 2015
- National Science Foundation (NSF) Travel Award, Regenerative Medicine Workshop at Hilton Head, 2015
- Outstanding Contribution, Cellular and Molecular Bioengineering Journal, 2015
Restuccia, A.; Fettis, M.M.; Hudalla, G.A. “Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis.” Journal of Materials Chemistry B, 2016 doi:10.1039/C5TB01780G.
Restuccia, A.; Tian, Y.F.; Collier, J.H.; Hudalla, G.A. “Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.” Cellular and Molecular Bioengineering, 2015, 8, 471-487.
Hudalla, G.A.; Sun, T.; Gasiorowski, J.Z.; Han, H.; Tian, Y.F.; Chong, A.S.; Collier, J.H. “Gradated assembly of multiple proteins into supramolecular nanomaterials.” Nature Materials, 2014, 13, 829-836.
Hudalla, G.A.; Modica, J.A.; Tian, Y.F.; Sun, T.; Rudra, J.S.; Chong, A.S. Mrksich, M.; Collier, J.H. “A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.” Advanced Healthcare Materials, 2013, 2(8):1114-9.