Chemical Engineering Dept. Chair & Dean’s Leadership Professor

Nanomedicine and magnetic nanoparticles

B.Sc., University of Puerto Rico, Mayagüez, 1998
M.S., Massachusetts Institute of Technology, 2001
M.S.C.E.P., Massachusetts Institute of Technology, 2001
Ph.D., Massachusetts Institute of Technology, 2002

Research Summary:

Dr. Rinaldi-Ramos’ research is focused on advancing the understanding and biomedical applications of suspensions of magnetic nanoparticles. Of particular interest are situations where the particles respond to magnetic fields by rotating, exerting forces/torques on biological structures, or dissipating the energy of the magnetic field in the form of heat. Work in Rinaldi-Ramos Research Laboratory spans theoretical and simulation investigation of magnetic nanoparticle response to magnetic fields, nanoparticle synthesis and modification, characterization of nanoparticle physical, chemical and magnetic properties, and testing the interactions of magnetic nanoparticles with cells and tissues.

Honors and Awards:

• Fellow, American Association for the Advancement of Science (AAAS), 2023
• Fellow, Society of Rheology, 2022
• UF HWCOE Doctoral Dissertation Advisor/Mentor Award, 2021
• Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2020
• University of Florida Term Professorship, 2017-2020
• Kavli Fellow and Invited Introductory Speaker, 28^th Annual Kavli Frontiers of Science Symposium, 2016
• Charles A. Stokes Term Professorship, University of Florida, 2015-2018.
• Excellence in Service Award, Department of Chemical Engineering, University of Florida, April 2015.
• Faculty Service Award, J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, April 2015
• International Journal of Nanomedicine Early Career Award, 2012
• Presidential Early Career Award for Scientists and Engineers (PECASE) 2006.
• National Science Foundation Early Career Award for Scientists and Engineers (CAREER Award), 2006
• J. Edward Vivian Award for Exemplary Performance and Commitment to the MIT David H. Koch School of Chemical Engineering Practice class of 1999-2000.
• National Science Foundation Graduate Research Fellow 1998-2001

Selected Publications:
Google Scholar Citations Link

Mythreyi Unni, Lorena Maldonado, Shehaab Savliwala, Brittany Partain, Pawel Grybos, Anna Koziol, Piotr Maj, Robert Szczygiel, Qingteng Zhang, Eric M. Dufresne, Alec Sandy, Suresh Narayanan, Kyle Allen, and Carlos M. Rinaldi-Ramos, “Fast nanoparticle rotational and translational diffusion in synovial fluid and hyaluronic acid solutions.” Science Advances, 7, eabf8467, 2021. [https://doi.org/10.1126/sciadv.abf8467]

Angelie Rivera-Rodriguez and Carlos M. Rinaldi-Ramos, “Emerging biomedical applications based on the response of magnetic nanoparticles to time-varying magnetic fields.” Annual Reviews in Chemical and Biomolecular Engineering, 12:20.1-20.23, 2021. [https://doi.org/10.1146/annurev-chembioeng-102720-015630]

Angelie Rivera-Rodriguez, Lan B. Hoang-Minh, Andreina Chiu-Lam, Leyda Marrero-Morales, Duane A. Mitchell, and Carlos M. Rinaldi-Ramos, “Tracking adoptive T cell immunotherapy using magnetic particle imaging.” Nanotheranostics, 5(4):431-444, 2021. [https://doi.org/10.7150/ntno.55165]

Andreina Chiu Lam, Edward Staples, Carl Pepine, and Carlos Rinaldi, “Perfusion, cryopreservation, and nanowarming of whole hearts using colloidally stable cryopreservation agent solutions.” Science Advances, 7(2):eabe3005, 2021. [https://doi.org/10.1126/sciadv.abe3005]

Zhi Wei Tay, Prashant Chandrasekharan, Andreina Chiu-Lam, Daniel Hensley, Rohan Dhavalikar, Xinyi Zhou, Elaine Yu, Patrick Goodwill, Bo Zheng, Carlos Rinaldi, Steven M. Conolly, “Magnetic Particle Imaging Guided Heating In Vivo using Gradient Fields For Arbitrary Localization of Thermal Therapy.” ACS Nano, 12(4):3699-3713, 2018. [http://doi.org/10.1021/acsnano.8b00893]

Lorena P. Maldonado-Camargo, Chuncheng Yang, and Carlos Rinaldi, “Scale-dependent rotational diffusion of nanoparticles in polymer solutions.” Nanoscale, 9(33):12039-12050, 2017. [doi:10.1039/C7NR01603D]

Mythreyi Unni, Amanda Uhl, Shehaab Savliwala, Benjamin Savitzky, Roham Dhavalikar, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and Carlos Rinaldi, “Thermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.” ACS Nano, 11(2):2284-2303, 2017. [http://doi.org/10.1021/acsnano.8b00893]

Lorena P. Maldonado-Camargo and Carlos Rinaldi, “Breakdown of the Stokes-Einstein relation for the rotational diffusivity of polymer grafted nanoparticles in polymer melts.” Nano Letters, 16:6767-6773, 2016. [doi: 10.1021/acs.nanolett.6b02359]

Camilo Velez, Isaac Torres-Díaz, L.P. Maldonado-Camargo, Carlos Rinaldi, and David P. Arnold, “Magnetic assembly and crosslinking of nanoparticles for releasable magnetic microstructures.” ACS Nano, 9(10):10165-10172, 2015. [doi: 10.1021/acsnano.5b03783]

Maribella Domenech, Ileana Marrero-Berrios, Madeline Torres-Lugo, and Carlos Rinaldi, “Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields.” ACS Nano, 7(6):5091-5101, 2013. [doi: 10.1021/nn4007048]

Mar Creixell, Ana C. Bohorquez, Madeline Torres-Lugo, and Carlos Rinaldi, “EGFR-targeted magnetic nanoparticle heaters can kill cancer cells without a perceptible temperature rise.” ACS Nano, 5(9), 7124-7129, 2011. [doi: 10.1021/nn201822b]