Fan Hong, Ph.D.

Fan Hong, Ph.D.
Hong Lab

125 Buckman Dr,
​Gainesville, FL 32603

​CLB 210C

Department Affiliation: Department of Chemistry

Assistant Professor


Postdoc – Wyss Institute  & Harvard University
Ph.D.  – Biodesign Institute & Arizona State University
B.S. –  Huazhong University of Science and Technology

Fan is interested in developing biomolecular tools with nucleic acids to dive into the complexity of biology (decoding and regulating cellular functions on the molecular basis at tissue scale). Before joining the faculty at the University of Florida, Fan was a Postdoc Fellow at Wyss Institute at Harvard University where he worked on the DNA advanced in situ spatial multi-omics (e.g., DNA thermal-plex) in the Yin Lab. Fan completed his Ph.D. at Biodesign Institute at Arizona State University and work in the Yan Lab, Green Lab , and Sulc Lab, where he developed methods to program nucleic acids in vitro (e.g., Framework DNA nanoarchitecture), in vivo (e.g., SNIPR) , and in silico (e.g., crowder-oxDNA) to address grand challenges with chemical approaches to biology. Those methods enable the control of nucleic acid folding into complex framework biomolecular architectures from the nanoscale to the macroscale, the regulation of cellular gene expression based on the single nucleotide mutation in cell with de-novo-designed RNA riboregulators, and investigating the biophysical behavior of nucleic acid folding in the crowding cellular environment with molecular dynamics. Fan is originally from Wuhan, China, where he earned his undergraduate degree at the Huazhong University of Science and Technology and stepped into the world of nucleic acids.