Biomimetic Cell Culture Systems to Replicate Mechanical Function In Vitro

Date(s) - 08/26/2013
4:00 pm

Chelsey Simmons, Ph.D., Assistant Professor, Mechanical & Aerospace Engineering

Abstract: Human organs are composed of dynamic, active tissues subject to a variety of mechanical stimuli like tensile strain and shear flow. We have designed, fabricated, and tested various tools to replicate aspects of the cardiovascular system in vitro, including substrate stiffness and strain. Future directions for my laboratory include development of electromechanical systems to promote immature and stem cell differentiation into mature cardiac tissue and of flow-based systems to model and examine normal and pathological renal tubule formation.

Dr. Simmons’ Lab: Biomimetic Actuators & Integrated Technology