Date/Time
Date(s) - 09/23/2024
3:15 pm - 4:15 pm
Location
HPNP Auditorium
Engineering 3D Lung Models to Advance Pulmonary Disease Research and Treatment
Chronic respiratory diseases are the third-leading cause of death globally. The only treatment for end stage lung disease is transplant, but even successful transplants have survival rates of 54% after 5 years and 32% after 10 years. There remains a critical unmet clinical need to understand underlying disease mechanisms and the normal repair processes present in health lungs to better treat these pervasive conditions. The Magin laboratory focuses on using innovative biomaterials, including dynamically stiffening systems and bioengineering approaches, such as 3D printing, to build in vitro models of chronic pulmonary diseases that can be combined with human cells to replicate key aspects of pathobiology not otherwise reproducible in animal models or with traditional cell-culture techniques. To create new tools that enable us to study the influence of cell-matrix and cell-cell interactions on disease progression in vitro, my laboratory designs and microfabricates a new class of phototunable, hybrid-hydrogel biomaterials and is uniquely positioned to conduct dynamic 3D studies using human cells, which are not currently possible in traditional models. Our goal is to better recapitulate the process of disease progression in vivo and contribute innovative approaches to prevention and intervention. Dr. Magin graduated from the University of Florida J. Crayton Pruitt Family Department of Biomedical Engineering with a PhD in 2010, and this talk will also guide attendees through her journey from a first-generation college student, through a PhD and postdoc, off to industry, and back into academia.
Bio:
Dr. Magin is an Associate Professor in the Departments of Bioengineering, Pediatrics and Medicine at the University of Colorado, Denver | Anschutz. Her research group uses biomaterials and bioengineering approaches, like 3D printing, to build 3D models of lung disease and repair. She is a recipient of an NSF CAREER Award, the American Thoracic Society Recognition of Early Academic Achievement Award, the Cellular and Molecular Bioengineering Rising Star Award, and the University of Florida’s 40 Gators Under 40 Alumni Award. Dr. Magin teaches Regulatory Affairs and Research Methods.