Critical Analysis of Hybrid and Mathematical Models for Educational Simulation of Pulmonary Gas Exchange

Date(s) - 06/20/2013
1:00 pm

Rujuta Munje, BME Masters Student

The Human Patient Simulator (HPS), designed and manufactured by CAE Healthcare Inc., is primarily used to train medical students. Certain inconsistencies are observed in the performance of the Lung Mechanics and Pulmonary Gas Exchange model of the HPS. The primary aim of CAE Healthcare, Inc. is to optimize the HPS implementation. HPS is a hybrid implementation that is supported by a software model of human physiology called Muse. For this thesis project, the performance of Muse with respect to respiratory system simulation was investigated. The conceptual model and corresponding mathematical model for the respiratory system of HPS simulation was studied thoroughly. A software implementation simulating this mathematical model has been established in MATLAB. This model was verified by comparing it to a set of analytical solutions obtained by varying input variables and initial conditions of state variables of the model. These analytical solutions are manually calculated by solving the set of ordinary differential equations simultaneously that form the mathematical model. A methodology of comparison has been developed to compare the implementation of Pulmonary Gas exchange on different platforms. This strategy is used to compare the performance of Muse and MATLAB implementation for specially designed scenarios
that are physiologically and academically relevant. The results obtained from both the implementations are in agreement when visually compared and are within the clinically valid range of the physiological data obtained from the literature. Certain abnormalities observed in the performance of the Muse software will be reported to CAE Healthcare,Inc.