High-throughput gigapixel imaging and the opportunities it opens up

Date(s) - 02/25/2013
4:00 pm - 5:15 pm

Dr. Guoan Zheng, Post-Doctoral Fellow, Caltech, Pasadena, CA

Microscopy has driven discoveries in biology for many centuries. However, a long-standing problem remains — one can either choose to view a small area of the sample in high-resolution or view a large area in low-resolution. In this talk, I will present a solution that eliminates this tradeoff, allowing us to have the best of both worlds. Our current prototype, readily implemented using a conventional microscope, is capable of providing a numerical aperture of 0.5, a field-of-view of 120 mm^2, and a resolution-invariant depth-of-focus of ~0.3 mm. Without involving any mechanical scanning, gigapixel images can be obtained in a simple, robust, and cost-effective manner. I will demonstrate the applications of our prototype for digital pathology, hematology, immunohistochemistry, and neuroanatomy. Furthermore, I will explore the possibility of using similar setups for 3D and lensless imaging. In summary, this innovation may pave the way for a turnkey solution that enables high-throughput imaging for the broad biomedical community.