Probing metabolism in vivo in real time

Date(s) - 03/28/2013
4:00 pm - 5:15 pm

Arnaud Comment, Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, Switzerland

The tremendous gain in signal-to-noise ratio resulting from hyperpolarization techniques and in particular dissolution dynamic nuclear polarization (DNP) opened new perspectives in biomedical magnetic resonance (MR) research. Hyperpolarization increases MR sensitivity by several orders of magnitude offering the opportunity to perform real-time in vivo MR spectroscopy experiments. It is thus possible to probe fast biochemical transformations from labeled precursors to metabolic products in vivo.