The prevalence of cardiovascular disease and the limited availability of suitable autologous transplant vessels for coronary and peripheral bypass surgeries is a significant clinical problem. To that end, Dr. Peter McFetridge and Doctoral Candidate Salma Amensag are exploring the capacity to control physical parameters such as vessel diameter, wall thickness, shape, and length are critical to match vessel compliance and tailor vessel specifications to distinct anatomical locations. As such, this approach opens new avenues in a range of tissue regenerative applications that may have a much wider clinical impact.

Rolling the Human Amnion to Engineer Laminated Vascular Tissues, Tissue Engineering Part C: Methods