Gregory Hudalla, Ph.D.

Gregory Hudalla
Gregory Hudalla, Ph.D.
Assistant Professor & J. Crayton Pruitt Family Term Fellow
Primary Faculty
Topics: 
Peptide-based nanomaterials and immune therapies
Address: 
1275 Center Drive, Biomedical Sciences Building J296, Gainesville, FL 32611
Office Phone: 
(352) 273-9326
Office Fax: 
(352) 273-9221
Home Page: 
Education: 
B.S., Chemical Engineering, Illinois Institute of Technology, 2004
M.S., Biomedical Engineering, University of Wisconsin, 2006
Ph.D. Biomedical Engineering, University of Wisconsin, 2010
NIH NRSA Post-doctoral Fellow, Surgery, University of Chicago, 2013

Research Summary:

Hudalla’s research creates functional biomaterials for therapeutic or diagnostic applications via molecular self-assembly. The Hudalla laboratory develops synthetic peptides that can assemble into a desired nano-scale architecture, and then uses these peptides as “tags” to organize biologically active molecules into functional nanomaterials. For example, their work has led to glycosylated nanofibers that inhibit the immunomodulatory activity of galectins, a family of carbohydrate-binding proteins. In another project, they combine enzymes and carbohydrate-binding proteins into catalytic nanomedicines that are anchored to tissues at an injection site via binding to extracellular carbohydrates. Hudalla's long-term goals are to create biomaterials that can modulate immune responses for the treatment of autoimmune diseases and aberrant inflammation.

Honors and Awards:

  • UF Preeminence Term Professor, 2018-2021
  • Early Career Award, University of Wisconsin-Madison, 2018
  • J. Crayton Pruitt Family Term Fellow, 2017-2020
  • National Institute of Biomedical Imaging and Bioengineering (NIBIB) Trailblazer R21 Award, 2017
  • Young Innovator by Cellular and Molecular Bioengineering, 2016
  • NSF CAREER Award, 2015
  • Faculty Teaching Excellence Award, University of Florida Department of Biomedical Engineering, 2015
  • Outstanding Contribution, Cellular and Molecular Bioengineering Journal, 2015

Selected publications:

Google Scholar Citations Link

SA Farhadi, E Bracho-Sanchez, MM Fettis, DT Seroski, SL Freeman, A Restuccia, BG Keselowsky, GA Hudalla. "Locally Anchoring Enzymes to Tissues via Extracellular Glycan Recognition." Nature Communications. 9, 4943 (2018)

Restuccia, A.; Fettis, M.M.; Hudalla, G.A. “Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis.” Journal of Materials Chemistry B, 2016 doi:10.1039/C5TB01780G.

Restuccia, A.; Tian, Y.F.; Collier, J.H.; Hudalla, G.A. “Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.” Cellular and Molecular Bioengineering, 2015, 8, 471-487.

Hudalla, G.A.; Sun, T.; Gasiorowski, J.Z.; Han, H.; Tian, Y.F.; Chong, A.S.; Collier, J.H. “Gradated assembly of multiple proteins into supramolecular nanomaterials.” Nature Materials, 2014, 13, 829-836.

Hudalla, G.A.; Modica, J.A.; Tian, Y.F.; Sun, T.; Rudra, J.S.; Chong, A.S. Mrksich, M.; Collier, J.H. “A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.” Advanced Healthcare Materials, 2013, 2(8):1114-9.​