Microfluidics & Biomedical Applications

Date(s) - 10/25/2010
5:00 pm - 6:00 pm

Z. Hugh Fan, PhD, Department of Mechanical & Aerospace Engineering

Microfluidics is to study fluids in microscale.  It is a field that promises to reach the holy grail of “lab-on-a-chip”.  In analogy to shrinking a computer from the size of a room in the 1950s to a laptop today, instruments for chemical and biological analyses may be miniaturized into microfluidic devices using modern microfabrication technology. Potential applications of the portable, miniaturized devices may include point-of-care testing (e.g., in emergency rooms), environmental monitoring, and detection of biowarfare agents in the field.  In this presentation, brief review will be given on the concept of microfluidics, device fabrication, and fluid manipulation in microscale.  The focus of the presentation will be on three biomedical applications: (1) microfluidics-enabled two-dimensional protein separation for biomarker screening; (2) toxin detection enabled by miniaturized protein expression arrays; and (3) concentration of cancer cells using microfluidic sorting devices.